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Longitudinal double-blind randomized trials are recommended to follow ACS patients until hs-CRP levels return to normal, and to assess the impact of statin choice in all-cause mortality, cardiac mortality, and new MACEs. High-sensitivity C-reactive protein (hs-CRP) has emerged to be a very useful and reliable clinical marker of primary as well as secondary cardiovascular morbidity and mortality. Methods In this prospective, open-label randomized trial, group A was given rosuvastatin 40 mg daily and group B was given atorvastatin 20 mg daily along with standard post-ACS therapy. Untreated nonculprit plaques were analyzed by optical coherence tomography for thin-cap fibroatheroma, minimum fibrous cap thickness, lipid arc, and lipid length. We correlated the means within each group (baseline vs. four weeks) by applying dependent T-test and within the two groups (at four weeks of group A vs. group B) by applying independent T-test. The aim of this study is to compare the effects of rosuvastatin and atorvastatin in lowering hs-CRP levels in statin-naive patients admitted with acute coronary syndrome (ACS). BMC Cardiovasc Disord. Cureus 11(6): e4898. In the Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin (STELLAR) trial, the efficacy of rosuvastatin calcium (Crestor) was compared with that of atorvastatin (Lipitor), simvastatin (Zocor), and pravastatin (Pravachol) for lowering plasma low-density lipoprotein cholesterol (LDL-C) after 6 weeks of treatment. Clipboard, Search History, and several other advanced features are temporarily unavailable. Prevalence of thin-cap fibroatheroma significantly decreased in the R10 and A20 groups (-48% and -53%, respectively, p <0.001 for intragroup comparisons). Please note that Cureus is not responsible for any content or activities contained within our partner or affiliate websites. 2019 May 15;123(10):1565-1571. doi: 10.1016/j.amjcard.2019.02.019. Jinnah Postgraduate Medical Centre issued approval MU/ECA/18/244. and Zhao L, Xu T, Li Y, Luan Y, Lv Q, Fu G, Zhang W. Lipids Health Dis. Lipid profile (mg/dL), hs-CRP (mg/L) and erythrocyte sedimentation rate (ESR) (mm/Hr) were recorded and measured as the baseline (before starting therapy) and then again after four weeks. Published: June 14, 2019. Hs-CRP has not only been regarded as a predictor of adverse cardiovascular outcomes and atherosclerosis but also as a mediator. Along with their lipid-lowering properties, statins also contribute to the alleviation of micro-inflammation and reduces pro-inflammatory markers. Privacy Policy Epub 2015 Dec 13. This deduces that the patients should’ve followed the treatment for a longer duration to reach the safe limits of hs-CRP. Between the groups, the test revealed that the rosuvastatin group showed significantly lower hs-CRP levels as compared to the atorvastatin group (P< 0.05). Serum lipid profile, hs-CRP, and ESR were recorded for all patients at baseline (before starting therapy) and then again after four weeks. Read our Reviewer Guide for more info. In this prospective, open-label randomized trial, group A was given rosuvastatin 40 mg daily and group B was given atorvastatin 20 mg daily along with standard post-ACS therapy. From baseline to 6 months to 12 months, minimum fibrous cap thickness increased in the R10 group (61.4 ± 15.9 µm to 120.9 ± 57.9 µm to 171.5 ± 67.8 µm, p <0.001) and the A20 group (60.8 ± 18.1 µm to 99.2 ± 47.7 µm to 127.0± 66.8 µm, p <0.001). As per guideline it was 40–80 mg for atorvastatin, while 20–40 mg for rosuvastatin. 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